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One hundred years ago, in January of 1907, Alois Alzheimer published his landmark paper about Auguste D. This is a perfect time to sit back and contemplate the field’s past accomplishments and future challenges. The Alzforum editors have compiled some mat
disease (Mann et al., 1980; Bondareff et al., 1982; Haglund et al., 2006). Tau pathology also occurs in LC
pharma picks them up for human translation (Prinz et al., 2011). Hyped coverage of such publications can
phases (see ARF related news story on McKhann et al., 2011; Albert et al., 2011; and Sperling et al.,
the best large population data out there. See Guskiewicz et al., 2005 and Guskiewicz et al., 2007.
that propagate may not always cause dysfunction (e.g., Liu et al., 2015). Rather, dysfunction may arise
cholinergic mechanisms (Ragozzini et al., 1998). Gabrielle Strobel: That is interesting. I look forward to
disease, the mutated protein also disturbs function of skin cells in patients (according to Seo et al.,
Searching for the wherewithal to push on with your work on a promising new Alzheimer therapy? The NIH offers funding for research support at every step of the process, from early drug discovery right through to phase 3 clinical trials, if you know where t
inhibitor, which blocks its translocation: dehydroxymethylepoxyquinomicin (Kubota et al., 2007). Lovastatin
Sweden, recently reported on selective cell vulnerability in motor neuron diseases (Hedlund et al., 2010).
important roles of protein acetylation. I am also referring to this month’s paper by Creppe et al., 2009 on
mild cognitive impairment to AD (see Hansson et al., 2006; Fagan et al., 2006; Shaw et al., 2009; and
described in the Farrer paper (Farrer et al., 2001) is a partially active mutant as described in our Nature
evidence (Connor et al.) that the HFE protein is found on brain capillaries, choroid plexus and ependymal
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
